Neural oscillations during cognitive processes in an App knock-in mouse model of Alzheimer’s disease pathology

In Vivo Experiments Methods

Animals

Data were obtained from eight homozygous male App^NL-G-F mice (generated by Saito and colleagues¹⁹ and obtained from the Janssen transgenic rodent facility, Belgium) and ten age-matched non-litter mates WT C57BL/6J male mice (Charles River, France). Mice were singly housed in individually ventilated cages under a reversed 12–12 light cycle (lights off 07:00–19:00; light intensity ~100 lux) under controlled environmental conditions throughout the study (22 ± 2 °C ambient temperature and relative humidity at 60%). Home cages were equipped with corn cob bedding, a tinted polycarbonate shelter and tissue for nesting material and ad libitum water. Throughout pre-training and cognitive testing, mice were provided with a restricted diet (Dustless precision pellets, Bioserv, USA) to maintain them at 80% free-fed weight to…