Assessment of executive function declines in presymptomatic and mildly symptomatic familial frontotemporal dementia: NIH-EXAMINER as a potential clinical trial endpoint

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dementianews
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This study evaluated longitudinal changes in executive functions, processing speed, and memory in the earliest stages of f-FTLD using the NIH-EXAMINER and paper-and-pencil measures. At baseline, mutation carriers performed worse on the NIH-EXAMINER Executive Composite than did noncarrier family members. Nonmutation carriers appeared to improve over time, possibly due to practice…

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