Transformation-based integration overview
Bringing together individual data types undoubtedly enriches the systematic view on the Alzheimer’s disease, giving researchers the opportunity to understand molecular mechanisms from the genetic to protein levels. However, it also involves some limitations of biological data integration due to its heterogeneous nature26 such as different formats and standards, lack of common name space, incompleteness, versions of data collections, and size differences. Currently in the field of omics integration there is an open question about which molecular level should be used to provide a flexible and effective way to describe a biological system on different levels22,26. The answer to this question is highly dependent on the available omics data sets. Our approach is meant to allow the researchers to transit from one layer of information to the other…
