We evaluated the risk of PPI use and the incidence of AD and other types of dementia in a community-based retrospective cohort. We considered at least a five-year lag window between the start of PPI usage and the incidence of any type of dementia. Our data analysis demonstrated no association between the use of PPIs and incidence of AD and a discretely increased risk of non-AD dementias after adjusting for comorbidities.
Detecting risk factors for dementia is a fundamental step for its prevention. Age is one of the most important risk factors for dementia. Therefore, as the global population of the world ages, the prevalence of dementia and especially AD is increasing37. Normally, the presence of health problems grows in the elderly, and as a result polypharmacy is common among this population. The medications used are often of special interest as a risk factor for dementia….
