Fig. 2

Macroscopic examples of AD-CBS and AD-AS; comparison of representative cases of AD-CBS (A, B, C) and AD-AS (D, E, F). The midsagittal view shows marked medial frontal atrophy, especially in paracentral lobule and perirolandic region (MTR) in AD-CBS (A), but not in AD-AS (D). Coronal sections show ventricular enlargement, with disproportionate enlargement of frontal compared with temporal horns of the lateral ventricle in AD-CBS (B) compared with AD-AS (E). Transverse sections of the midbrain show decreased neuromelanin pigment in the lateral substantia nigra (SN) in AD-CBS (C) compared with AD-AS (F). Abbreviations: AD, Alzheimer’s disease; AD-AS, AD patients with typical amnestic syndrome; AD-CBS, AD patients with CBS; AS, amnestic syndrome; CBS, corticobasal syndrome; MTR, motor cortex.