Intranasal delivery of MSCs provides hope for treating Alzheimer’s disease

Intranasal delivery of MSCs provides hope for treating Alzheimer's disease
Intranasal injection (IN) of preconditioned MSC-derived EVs (MSC-EVs) affects microglia activation in the brain of 3xTg-AD mice. The image shows the distribution of Iba-1+-microglia (in green) in the CA1 medial hippocampus of PBS- (CTRL) and EV-treated (MSC-EVs) mice. Nuclei (in blue) were stained with DAPI. Scale bar: 100mm. Credit: AlphaMed Press

In the search for a cure for Alzheimer’s disease, mesenchymal stem cells and their derived extracellular vesicles (MSC-EVs) offer much promise, thanks to their protective and anti-inflammatory properties. The results from a new study done on mice, released today in STEM CELLS Translational Medicine, strengthens this idea by showing for the first time that MSC-EVs delivered by way of the nasal passages reduce inflammation—believed to be a prime factor in Alzheimer’s disease. They…

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