Monday, September 27, 2021

The case for low-level BACE1 inhibition for the prevention of Alzheimer disease

1.Selkoe, D. J. & Hardy, J. The amyloid hypothesis of Alzheimer’s disease at 25 years. EMBO Mol. Med. 8, 595–608 (2016).CAS  PubMed  PubMed Central  Article  ...

Copper in Glucose Intolerance, Cognitive Decline, and Alzheimer Disease

Trace metal dyshomeostasis has been linked to loss of cognitive performance. In particular, a disturbance in the regulation of copper (Cu), characterized by an increase in circulating Cu not bound to ceruloplasmin (non-Cp Cu),...

Odor Identification Testing Can Assist in the Clinical Distinction Between Psychiatric Disorders and Neurological/Neurodegenerative...

Background/Objectives: The aim was to identify whether performance on olfactory identification can distinguish neurological/neurodegenerative disorders (NNDs) from primary psychiatric disorders (PPDs). Methods: This is a cross-sectional retrospective study of inpatients assessed in Neuropsychiatry, Royal Melbourne...

How scents take on meaning: Neurophysiology — ScienceDaily

Dr. Christina Strauch, PhD student Thu-Huong Hoang, and Professor Denise Manahan-Vaughan from the Department of Neurophysiology collaborated on the study with Professor Frank Angenstein from the German Center for Neurodegenerative Diseases (DZNE) in Magdeburg. Olfactory...

Can we learn lessons from the FDA’s approval of aducanumab?

1.Alzheimer’s Disease International. Numbers of people with dementia around the world. https://www.alzint.org/u/numbers-people-with-dementia-2017.pdf (2020).2.Rizzi, L., Rosset, I. & Roriz-Cruz, M. Global epidemiology of dementia: Alzheimer’s and vascular types. Biomed. Res. Int. 2014, 908915 (2014).PubMed  ...

An efficient context-aware screening system for Alzheimer’s disease based on neuropsychology test

Neuropsychological tests and data collectionThe present study was approved by the Ethics Committee and Institutional Review Board at National Taiwan University Hospital, and all the experiments were performed in accordance with the guidelines and...

Scientists pinpoint the uncertainty of our working memory — ScienceDaily

The human brain regions responsible for working memory content are also used to gauge the quality, or uncertainty, of memories, a team of scientists has found. Its study uncovers how these neural responses allow...

The RIDR Program: Providing Early Career Opportunities for Historically Underrepresented Student Groups

“It is critical that we bring people with diverse perspectives and backgrounds into medicine. Our medical teams must reflect the diversity of our communities in order for patients to have...

Treatment of canine cognitive dysfunction with novel butyrylcholinesterase inhibitor

This study shows that a newly developed BChEi could be used in treating cognitive decline in dogs. In dogs with moderate cognitive impairment, treatment was associated with the improved clinical rating of cognitive abilities....

Accelerated functional brain aging in pre-clinical familial Alzheimer’s disease

Cohorts and participantsDominantly Inherited Alzheimer Network—DIANDIAN is a multisite longitudinal study71, which enrolls individuals age 18 and older who have a biological parent that carries a genetic mutation responsible for ADAD. They all underwent...
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