Peripheral immune cell imbalance is associated with cortical beta-amyloid deposition and longitudinal cognitive decline

Baseline characteristics and group comparisons for the overall cohort are shown in Table 1. Compared to the NC group, the MCI group was younger (mean ± SD: MCI 73 ± 7.6 vs. NC 75 ± 5.7 years, p < 0.001) and had a higher proportion of males (MCI 59% male vs NC 50% male, p = 0.004). The MCI and AD groups had fewer years of education (MCI 15.9 ± 2.9 vs. NC 16.3 ± 2.7 years, p = 0.03; AD 15.1 ± 3.0 vs NC, p = 0.003), fewer APOE ε2 carriers (MCI 6% vs. NC 14%, p < 0.001; AD 4% vs. NC, p < 0.001), and more APOE ε4 carriers (MCI 49% vs. NC 27%, p < 0.001; AD 68% vs. NC, p < 0.001) than the NC group. The MCI and AD groups also had higher NLR (MCI 2.49 ± 1.17 vs. NC 2.32 ± 1.00, p = 0.02; AD 2.74 ± 1.30 vs. NC, p < 0.001), lower LMR (MCI 4.69 ± 1.85 vs. NC 5.11 ± 3.35, p = 0.008; AD 4.57 ± 1.67 vs….