A research team from the University of Cologne and the Universities of Mannheim and Heidelberg has found that even the single administration of alcohol permanently alters the morphology of neurons. In particular, the structure of the synapses as well as the dynamics of mitochondria — the powerhouses of the cell — are influenced by alcohol. Using the genetic model system of the fruit fly Drosophila melanogaster, Professor Dr Henrike Scholz and her team members Michèle Tegtmeier und Michael Berger showed that changes in the migration of mitochondria in the synapses reduce the rewarding effect of alcohol. These results suggest that even a single consumption event can lay the foundation for alcohol addiction.
The study “Single-dose ethanol intoxication causes acute and lasting neuronal changes in the brain” has appeared in PNAS (Proceedings of the National Academy of Sciences).
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