A University of Iowa neuroscience research team has identified a fundamental biochemical mechanism underlying memory storage and has linked this mechanism to cognitive deficits in mouse models of Alzheimer’s Disease and Related Dementias.
While working to understand how memories are formed and stored in the brain, the team identified a novel protein folding mechanism in the endoplasmic reticulum that is essential for long term memory storage. They further demonstrated that this mechanism is impaired in a tau-based mouse model of Alzheimer’s disease and that restoring this protein folding mechanism reverses memory impairment in this mouse model for the study of dementia. The findings are published in the March 23 issue of the journal Science Advances.
The team was led by Snehajyoti Chatterjee, PhD, a research associate in the lab of Ted Abel, PhD, Director of the Iowa Neuroscience…
