New framework for analyzing Alzheimer’s disease identifies not one form, but three

New framework for analyzing Alzheimer’s disease identifies not one form, but three
Fig. 1: The probabilistic model of Alzheimer disease. Credit: DOI: 10.1038/s41583-021-00533-w

According to the commonly accepted model, Alzheimer’s disease is characterized by an ineluctable sequence, from the accumulation of toxic proteins in the brain to dementia resulting from neurodegeneration. While this deterministic sequence is sometimes true, it does not seem to be the case for all patients. Moreover, the disappointing results of recently marketed drugs have highlighted the need to reconsider this disease, which affects nearly 10 million people in Europe. A European consortium of physicians and scientists, led by the University of Geneva (UNIGE) and the University Hospitals of Geneva (HUG), in Switzerland, which also includes INSERM in France, has analyzed the data presented in…

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