Grey matter networks in women and men with dementia with Lewy bodies

Participants

In this cross-sectional multicentre study, we included DLB patients from three centres of the E-DLB consortium (Prague, Strasbourg, Amsterdam) as well as the Mayo Clinic DLB cohort. We previously used the same cohort to identify sex differences in regional brain volumes and cortical thickness using univariate analyses²¹. Probable DLB was diagnosed according to the 2005 International Consensus Criteria⁴². Patients were further characterized by the presence or absence of the core clinical features of DLB (parkinsonism, visual hallucinations, cognitive fluctuations, and REM sleep behaviour disorder). Additionally, performance in the Mini-Mental State Examination (MMSE) was assessed as a measure of global cognition. To assess the presence of Alzheimer’s disease (AD) co-pathology, AD biomarkers were measured in cerebrospinal fluid in E-DLB centres and with positron emission…