The power of neighbors: Neighboring synapses shape learning and memory

A researcher at the University of Basel, in collaboration with a colleague in Austria, has developed a new model that provides a holistic view on how our brain manages to learn quickly and forms stable, long-lasting memories. Their study sheds light on the crucial role of interactions among neighboring contact sites of nerve cells for brain plasticity — the brain’s ability to adapt to new experiences.

In 1949, the Canadian psychologist Donald O. Hebb described that connections between neurons become stronger when the neurons are active at the same time and that strengthened connections facilitate signal transmission. The ability of our brain to modify the connections between neurons is fundamental for learning and memory.

“It has long been assumed that these adaptations occur mostly on a one-on-one basis at specific synapses, the contact sites between two neurons,” explains Dr….

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