Switch of innate to adaptative immune responses in the brain of patients with AD
To investigate the cellular dynamics associated with innate and adaptative immune responses in the brain of patients with different degrees of tauopathy, microglia and white blood cell populations from the middle temporal gyrus (MTG) of 42 elderly individuals diagnosed with dementia and 42 age-matched healthy individuals8 were analyzed. Unsupervised clustering identified 26 immune cell clusters expressing PTPRC (CD45) that could be annotated using a combination of cell markers such as ITGAM (CD11B), TREM2, P2RY12 (microglia), CD3D, CD3G (T cells), CD19, JCHAIN (B cells), MRC1 (macrophages), S100A8, FCGR3A, NR4A1 (monocytes/neutrophils), and other genes differentially expressed in each cluster compared to all others (Fig. 1, Supplementary Fig. 1, Supplementary Table 1). Based on these profiles, clusters of…
