Participant characteristics
A total of 548 participants in the BioFINDER-2 cohort met the criteria to be included in the present analysis based on the availability of at least one of the plasma biomarkers listed below and a tau-PET scan. The average age of the cohort was 71.0 ± 8.6 years, with 45% of participants being female, and an overall tau-PET positivity rate of 37% (see Methods for details). Participants had subjective cognitive decline (n = 135), mild cognitive impairment (n = 181), or different forms of dementia (n = 225)—specifically AD dementia (n = 140), bvFTD (n = 16), svPPA (n = 3), nfvPPA (n = 1), DLB (n = 24), dementia with Parkinson’s disease (n = 7), vascular dementia (n = 16) and unclassified dementia (n = 24). Among TRIAD participants meeting the inclusion criteria (n = 179), patients had a mean age of…
