Participants and data
This is a natural history, non-interventional study of cognitively normal individuals ages 35–65 years, carrying risk factors for late-onset AD such as a family history and/or APOE4 genotype. Participants were recruited at the Weill Cornell Medicine (WCM) Alzheimer’s Prevention Program between 2018 and 2023 by self-referral, flyers, and word of mouth.
Our inclusion and exclusion criteria were previously described40,41,42,43. Briefly, all participants had Montreal Cognitive Assessment (MoCA) score ≥ 26 and normal cognitive test performance by age and education40,41,42,43. Exclusion criteria included medical conditions that may affect brain structure or function (e.g., stroke, any neurodegenerative diseases, major psychiatric disorders, hydrocephalus, demyelinating disorders such as Multiple Sclerosis, intracranial mass, and infarcts on MRI), use of…
