Characteristics of the study population
A total of 2136 participants were included in the present study, including 1297 (60.7%) CU, 217 (10.2%) MCI, 369 (17.3%) AD and 253 (11.8%) PRO (Table 1). Within the PRO group, 117 (46.3%) participants progressed from CU to MCI, 41 (16.2%) participants progressed from CU to AD, and 95 (37.5%) participants progressed from MCI to AD. Of the 2136 participants, 1590 (74.4%) had never diagnosed with cancer (C−), and 546 (25.6%) had a history of cancer (C+) at the time of enrollment (Table 1). Of the 1590 C− participants, 930 (58.5%), 170 (10.7%), 296 (18.6%), 194 (12.2%) belonged to the CU, MCI, AD, and PRO groups, respectively (Fig. 2A). Of the 546 C + participants, 367 (67.2%), 47 (8.6%), 73 (13.4%) and 59 (10.8%) belonged to the CU, MCI, AD, and PRO groups, respectively (Fig. 2B). The averaged age and distribution of sex for participants…
