Cohort characteristics
The cohort consistent of 47 IDCD participants that had both amyloid-PET and MRI (Fig. 1, mean age = 78Y, SD = 4; 64% men; mean education = 14Y, median MMSE = 28, Table 1). The median duration of type-2 diabetes at time of PET was 16 years (range 13–21) and participants’ mean glycemic control levels suggests a relatively well controlled sample (HbA1c 6.7% (SD = 1.1%)).
Flowchart of the study cohort. IDCD Israel Diabetes and Cognitive Decline Study.
Amyloid SUVR and cognitive functioning
Higher Aβ-SUVR was associated with lower global cognitive functioning, adjusting for demographics and the time interval between PET and cognitive testing (Model 1: β = − 1.30, SD = 0.47, p = 0.01; Table 2). The association of Aβ-SUVR with global cognition was essentially unchanged with increasing degree of…
