Altered cerebrovascular-CSF coupling in Alzheimer’s Disease measured by functional near-infrared spectroscopy

Measurement protocol

The data collection followed the guidelines established by the Declaration of Helsinki and all participants signed informed consent letter prior to the measurements. All measurements took place in Oulu University Hospital, Oulu, Finland. This study was approved by the regional medical research ethics committee of the Wellbeing services county of North Ostrobothnia. A sample of 8 patients (6 females, 62.6 ± 2.1 year-old) with AD and 14 age-matched controls (6 females, 63.6 ± 2.9 year-old) participated in this study, who received detailed explanation before signing the consent letter. Most of the participants also filled the mini-mental state exam (MMSE) prior to the measurements. Based on the MMSE score, 22.8 ± 1.6 and 28.5 ± 1.5 for AD and controls respectively, AD patients were categorized in a mild dementia19.

During measurement, all…

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