Fatal iatrogenic cerebral β-amyloid-related arteritis in a woman treated with lecanemab for Alzheimer’s disease

Inclusion and ethics statement

We confirm that our research complies with all pertinent ethical regulations, including CARE guidelines and the Declaration of Helsinki principles. The patient’s surrogates provided informed consent to participate in this case report. Vanderbilt University Medical Center’s Institutional Review Board provided ethical oversight as part of our ongoing Observational Study of CAA and Related Disorders (OSCAAR), protocol number 180287.

Post-mortem MR imaging

Coronal tissue slabs were sliced coronally and embedded in 1% agarose under degassing conditions, with care to avoid air bubbles. Post-mortem susceptibility weighted imaging (SWI) and T2-weighted FLuid Attenuated Inversion Recovery (FLAIR) MRI were obtained on both 3.0 T (Philips Ingenia) and 7.0 T (Philips Achieva) human clinical scanners using 32-channel phased array reception. 3.0 T SWI…

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