Participants characteristics
The BioFINDER-2 cohort included 448 individuals, the majority of whom had cognitive impairment (281, 63%): 81 cognitively unimpaired Aβ negative (CU−), 79 cognitively unimpaired Aβ positive (CU+), 90 Aβ positive with mild cognitive impairment (MCI+), 102 Aβ positive with AD dementia (AD+) and 96 with other dementias (non-AD) (Table 1). The average age was 70.9 ± 8.4 years (mean ± s.d.), 221 (49.3%) were women and 258 (57.6%) were APOE ε4 carriers. The Knight ADRC cohort included 219 individuals, most of whom were cognitively unimpaired (171, 78%): 83 CU−, 88 CU+, 35 very mild AD and 13 AD+. The average age was 71.2 ± 6.6 years, 112 (51.1%) were women and 96 (43.8%) were APOE ε4 carriers (Extended Data Table 1). CSF biomarkers were measured in the BioFINDER-2 and the Knight ADRC cohorts, including MTBR-tau243 concentration, as…
