Modulating heart rate oscillation affects plasma amyloid beta and tau levels in younger and older adults

Baseline characteristics of participants

The male and female ratio was similar across age groups and conditions (Table 1). At baseline, in neither age cohort did the Osc+ and Osc− groups differ significantly in plasma Aβ, plasma tau, age, body mass index, waist hip ratio, blood pressure, sleep, nor heart rate variability (Table 2). In addition, we compared males to females for the same baseline measures of Table 2 and reported the results in Supplementary Table. There was no significant baseline difference in CREB, bootstrap Z = 1.31, p = 0.19 (available only for 54 younger adults).

We then tested age differences in the six biomarkers (Aβ42, Aβ40, tTau, pTau-181, Aβ42/Aβ40 ratio and pTau-181/tTau ratio) at baseline. We adjusted p values to control…