In this study, we expanded previous hypothesis-driven MRI subtyping studies in DLB by conducting a data-driven MRI subtyping. We included a relatively large multi-center cohort including countries from Europe and the US. We found 3 subtypes within DLB: (1) a cortical predominant subtype, which included older patients with lower GM volumes and worse global cognition; (2) a fronto-occipital predominant subtype with intermediate GM volumes; and (3) a subcortical predominant subtype, which included younger patients with higher GM volumes and a higher frequency of CF. Differences in GM volumes and global cognition were independent of age.
The cortical predominant subtype had the lowest GM volumes across all cortical regions, as well as the worst global cognitive performance. This subtype resembles the widespread cortical atrophy subtype with worst cognitive performance previously reported…
