Data sources
The data used in the study are from two large-scale EHR databases: the Research Patient Data Registry in the United States at Mass General Brigham Healthcare (US RPDR) and the Clinical Practice Research Datalink in the United Kingdom (UK CPRD).
US RPDR
The study cohort was selected from the RPDR registry13. RPDR is a longitudinal centralized clinical data registry with ~6.5 million patients mainly from the Boston area as of June 2020. The data are collected from EHR systems within Mass General Brigham (MGB) Healthcare (formerly Partners Healthcare), comprising two major academic hospitals, as well as several community hospitals and community health centers in the Boston area. Death records are updated periodically from the US Social Security Death Index (2007–2017). Use of RPDR data for this study was approved by the institutional review board (IRB) of MGB.
UK CPRD
The…
