Animals
Adult male C57BL mice were purchased from SPF Biotechnology (Beijing, China). α-Syn knockout mice were provided by Professor Yang Hui of Capital Medical University. All animals were housed at room temperature under a 12/12 h light/dark cycle and had free access to food and water. All animal experiments were approved by the Animal Care and Use Committee of the Institute of Animal Management, Capital Medical University (permit no. AEEI-2021-058), and conducted in accordance with ethical requirements and ARRIVE guidelines.
Hypoxic treatment
All mice were randomly assigned to the control group and each model group. Hypoxic mice were administered hypoxic treatment in a closed hypoxic chamber (China Innovation Instrument Co., Ltd, Ningbo, Zhejiang, China), which accurately set the desired hypoxic concentration and pattern. For chronic hypoxia, mice were treated continuously with…
