Participants
A total of 19 patients in the mild phase of AD (Clinical Dementia Rating = 1) and 19 controls, recruited from the community with no evidence of cognitive impairment or other relevant pathologies, were enrolled in this study. Patients were recruited at the Neurology department of the Centro Hospitalar e Universitário de Coimbra (CHUC), where AD diagnosis was made by two experienced neurologists at the Memory Clinic of the Neurology department of CHUC. The clinical diagnosis was supported by biological biomarkers (cerebrospinal fluid – CSF and/or 11C-PiB PET SUVR).
Regarding 11C-PiB PET SUVR, its positivity was determined by an experienced nuclear medicine medical doctor relying on the regional visual analysis of the images, with emphasis to frontal, parietal/precuneus, temporal, anterior and posterior cingulate, basal ganglia and occipital cortices (a homemade machine…
