Large Study Finds Head Knocks Are Not Associated with Alzheimer’s Disease

Headshot of Michael Weiner, UCSF Radiology faculty member and principal investigator at ADNI Do head knocks eventually lead to Alzheimer’s disease? Many studies have reported this link, but a new large study has unexpectedly found the opposite. Michael Weiner, MD, professor in residence in the UC San Francisco Department of Radiology and Biomedical Imaging and the San Francisco Veterans Affairs Medical Center (SFVAMC) set out to examine the question in Vietnam veterans.

His study, reported in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, had one key difference – how Alzheimer’s disease was defined. While in previous studies Alzheimer’s disease has been diagnosed by a physician using tests of cognition and function, in this study, researchers used biological indicators of Alzheimer’s disease.

These so-called biomarkers reflect the hallmark lesions associated with the disease – β-amyloid plaques and tau fibrils – along with showing…

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