Study population
This study was exempted from local institutional review board approval, as all neuroimaging and clinical data were obtained in deidentified format upon request from external study centers, who ensured compliance with ethical guidelines and informed consent for all participants. No compensation was provided to participants.
We collected demographics, medical history, neuropsychological tests, and functional assessments as well as magnetic resonance imaging (MRI) scans from 8 cohorts (Table 1), totaling 8916 participants after assessing for inclusion criteria. There were 4550 participants with normal cognition (NC), 2412 participants with mild cognitive impairment (MCI), 1606 participants with Alzheimer’s disease dementia (AD) and 348 participants with dementia due to other causes. The eight cohorts include the Alzheimer’s Disease Neuroimaging Initiative (ADNI)…
