Participants
All participants or their designee provided written consent with approval of the Mayo Clinic Foundation and Olmsted Medical Center Institutional Review boards. All participants in the Mayo Clinic Rochester Alzheimer’s Disease Research Center (ADRC) and the Mayo Clinic Study of Aging (MCSA) that met our inclusion criteria were included in this study. The Mayo Clinic Rochester ADRC is a longitudinal cohort study that enrolls subjects from the clinical practice at Mayo Clinic in Rochester, MN24. The MCSA is a population-based study of cognitive aging among Olmsted County, MN residents50. Enrolled participants are adjudicated to be clinically normal or cognitively impaired by a consensus panel consisting of study coordinators, neuropsychologists, and behavioral neurologists. Methods for defining clinically unimpaired, mild cognitive impairment and dementia in both studies…
