Model description
We initially constructed three CBNs to capture A1/A2 and pan-reactive astrocyte activity. The literature backbone of the A1 astrocyte activity CBN consisted of 401 nodes connected by 732 edges, supported by data from 62 publications. After data-driven expansion, the A1 CBN was supported by data from 76 relevant peer-reviewed articles. The expanded A1 network contained 502 nodes and 893 edges. The literature backbone of the A2 astrocyte activity CBN consisted of 334 nodes connected by 504 edges, supported by data from 43 publications. After data-driven expansion, the A2 astrocyte activity network model was computed from 81 publications and consisted of 535 nodes and 842 edges. The literature backbone of the pan-reactive astrocyte CBN consisted of 458 nodes connected by 816 edges, supported by data from 70 publications. After data-driven expansion, the pan-reactive…
