New drug screening method answers why Alzheimer’s drugs fail, suggests new targets

alzheimers
Credit: Pixabay/CC0 Public Domain

By analyzing disease mechanisms in human neurons, researchers led by the University of California San Diego developed a new method to screen drugs for treating Alzheimer’s disease. Their work sheds light on why Alzheimer’s drugs so far have been ineffective at curing or reversing the disease and identifies new targets for drug development.

The findings, reported in a paper published Jan. 27 in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, could help pave the way for radically new therapeutic approaches to treating Alzheimer’s.

Drug development for Alzheimer’s has long been driven by the hypothesis that

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