Importance of CSF-based Aβ clearance with age in humans increases with declining efficacy of blood-brain barrier/proteolytic pathways

  • 1.

    Potter, R. et al. Increased in vivo amyloid-β42 production, exchange, and loss in presenilin mutation carriers. Sci. Transl. Med. 5, 189ra77–189ra77 (2013).

    PubMed 

    Google Scholar
     

  • 2.

    Patterson, B. W. et al. Age and amyloid effects on human central nervous system amyloid-beta kinetics. Ann. Neurol. 78, 439–453 (2015).

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • 3.

    Elbert, D. L., Patterson, B. W. & Bateman, R. J. Analysis of a compartmental model of amyloid beta production, irreversible loss and exchange in humans. Math. Biosci. 261, 48–61 (2015).

    CAS 
    PubMed 

    Google Scholar
     

  • 4.

    Bateman, R. J. et al. A γ-secretase inhibitor decreases amyloid-beta production in the central nervous system. Ann. Neurol. 66, 48–54 (2009).

    CAS 
    PubMed 

  • Read more…