Study now links non-mutated Apolipoprotein E to dementia in the aging brain

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dementianews
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Study now links non-mutated Apolipoprotein E to dementia in the aging brain
Immunofluorescence microscopy showing a single neuritic amyloid plaque with the localization of Apolipoprotein E (ApoE) (green; A), complement protein C4 (red; B), and Tau (white; C) proteins in amygdala. This is from an individual with the APOE ε3/3 genotype (Case 1068). In the depicted plaque-like structure, the ApoE signal is strongest in the plaque core (arrow in panel A), whereas the C4 signal is also strong in the periphery (arrow in panel B). The Tau-immunoreactive structures are often outside the ApoE or C4 signal (arrow in panel C). Panel D shows all three colors, and yellow depicts green-red regions of overlap. The ApoE antibody labels small vessels (large arrowhead in panel A) and glial profiles (smaller arrowhead in panel A) that are not labeled by the C4 antibody. Scale bar = 50 μm. Credit: The…

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