The image shows neuronal cell nuclei of the dentus gyratus (yellow) and associated blood vessels (red). By varying the magnification of the X-ray optics, one can “zoom in” on the densely packed band of neurons (in the red oval) and also resolve the substructure of the cell nucleus (blue oval). The study showed a change in the cell nucleus structure occurring in Alzheimer’s disease towards a more compact and heterogeneous structure, which could be explained by a change in the packing density of the DNA. Credit: M. Eckermann/T. Salditt
What changes occur in parts of the brain affected by neurodegenerative disease? How does the structure of the neurons change? Some pathological changes in the tissue are easy to identify using standard microscopy. For example, the protein deposits known as…
The complete workflow is depicted in Fig. 1. To investigate the association between NPIs and AD, we initially conducted preprocessing and integration of biomedical triples...
Compared with other neurologic problems, few films have been dedicated to degenerative dementia. To our knowledge, this is the first systematic review about the...
