New mouse model mimics earliest stages of Alzheimer’s disease

New mouse model mimics earliest stages of Alzheimer’s disease
Figure 1: The new RIKEN model mice show hallmark signs of Alzheimer’s disease in the brain—both amyloid plaques (blue) and inflammatory signals (green and red). Credit: RIKEN Center for Brain Science

Drug hunters hoping to prevent or delay the onset of Alzheimer’s disease take note—a new mouse model developed at RIKEN offers a powerful platform for evaluating potential therapies designed to combat the neurodegenerative disease in its earliest stages.

Alzheimer’s is globally the most common neurodegenerative disorder. Many compounds that showed promise in models of the disease subsequently flopped in clinical trials on people. One reason for…

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