Newswise — New research from the University of Chicago points to microglia, key immune cells in the brain, as a key mediator in the relationship between the gut microbiome and b-amyloid deposits in male mice in a model of Alzheimer’s disease. The results, published on December 2 in the Journal of Experimental Medicine, indicate that the brain’s immune cells and their connection to our gut microbes may be an important target for preventing and treating dementia in human patients.
The study builds off of previous research showing that perturbations to the gut microbiome, induced by treatment with antibiotics during early life, could reduce some of the hallmark signs of Alzheimer’s disease (AD) in male, but not female, mice.
“Our past work has shown that if you give mice antibiotics beginning shortly after birth, you see a reduction of amyloid deposition specifically in male…
