Immune cells in the brain play key role in relationship between gut microbes and b-amyloid deposits

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dementianews
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Immune cells in the brain play key role in relationship between gut microbes and -amyloid
Microglia in the brain of male mice with Alzheimer’s Disease have a “neurodegenerative” appearance and is associated with amyloid beta plaques in the brain (left), while treating the mice with antibiotics early in life leads to “neuroprotective” microglia and reduced amyloidosis (middle). The beneficial effects of antibiotics can be reversed with a simple fecal matter transplant (right). Credit: From Dodiya et al., Journal of Experimental Medicine, 2021

New research from the University of Chicago points to microglia, key immune cells in the brain, as a key mediator in the relationship between the gut microbiome and b-amyloid deposits in male mice in a model of Alzheimer’s disease. The results, published on December 2 in the Journal of Experimental Medicine, indicate that the…

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