Physical activity may improve Alzheimer’s disease outcomes by lowering brain inflammation

Physical activity may improve Alzheimer's disease outcomes by lowering brain inflammation
Conceptual diagram of moderated mediation models. Models examine the mediating effect of inferior temporal microglial activation (PAM IT) on the relationship between physical activity and global cognitive outcomes or synaptic integrity markers in the inferior temporal gyrus. Credit: Casaletto et al., JNeurosci 2021

No one will disagree that an active lifestyle is good for you, but it remains unclear how physical activity improves brain health, particularly in Alzheimer’s disease. The benefits may come about through decreased immune cell activation, according to new research published in JNeurosci.

Microglia, the brain’s resident immune cells, activate to…

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