Restoring normal sleep reduces amyloid-beta accumulation in mouse model of Alzheimer’s disease

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dementianews
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Restoring normal sleep reduces amyloid-beta accumulation in mouse model of Alzheimer's disease
The white line represents a hypnogram that indicates what state the brain is in during your sleeping time: active wake, quiet wake, rapid eye movement (REM) sleep, or slow wave sleep (SWS). In normal animals (and humans), it is typical to fluctuate between different states over the course of your sleeping time. Activity of the thalamic reticular nucleus (TRN) is critical during sleep, as it helps maintain stable sleep states and promotes the pattern of neuronal activity that underlies SWS. (Bottom left) However, in mice and patients with Alzheimer’s disease (AD), the activity of the TRN is lower than normal. When the TRN is not active, sleep becomes fragmented. In addition, there is less time spent in SWS, the deep restorative sleep during which the brain clears out toxins and metabolites produced throughout…

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