Cerebrovascular abnormalities in Alzheimer’s disease: An adrenergic approach

Aging-US: Cerebrovascular abnormalities in Alzheimer's disease: adrenergic approach
Α1AR-mediated downstream signaling pathway involved in Aβ-induced cerebrovascular abnormalities. Credit: Song Li

Aging-US has published “Involvement of cerebrovascular abnormalities in the pathogenesis and progression of Alzheimer’s disease: an adrenergic approach” which reported that alzheimer’s disease, as the most common neurodegenerative disease in elder population, is pathologically characterized by β-amyloid plaques, neurofibrillary tangles composed of highly-phosphorylated tau protein and consequently progressive neurodegeneration.

Increasing lines of evidence from both clinical and preclinical studies have indicated that age-related

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