Cohorts and participants
Dominantly Inherited Alzheimer Network—DIAN
DIAN is a multisite longitudinal study71, which enrolls individuals age 18 and older who have a biological parent that carries a genetic mutation responsible for ADAD. They all underwent clinical and cognitive assessments, genetic testing, and imaging (magnetic resonance imaging [MRI] and amyloid-positron emission tomography [PET]). Data has been obtained after request and IRB approval (information can be found at dian.wustl.edu/our-research/observational-study/). Baseline data from cognitively unimpaired mutation carriers and non-carriers archived in the DIAN data freeze 10 (January 2009 to May 2016) were used in the present study. All selected individuals had a Clinical Dementia Rating (CDR)72 scale of 0. Baseline data from 280 cognitively unimpaired individuals (mutation carriers and non-carriers) aged between 18…
