Microglial activation and tau propagate jointly across Braak stages

  • 1.

    Ising, C. et al. NLRP3 inflammasome activation drives tau pathology. Nature 575, 669–673 (2019).

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • 2.

    Salter, M. W. & Stevens, B. Microglia emerge as central players in brain disease. Nat. Med. 23, 1018–1027 (2017).

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • 3.

    Sheffield, L. G., Marquis, J. G. & Berman, N. E. Regional distribution of cortical microglia parallels that of neurofibrillary tangles in Alzheimer’s disease. Neurosci. Lett. 285, 165–168 (2000).

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • 4.

    Serrano-Pozo, A. et al. Reactive glia not only associates with plaques but also parallels tangles in Alzheimer’s disease. Am. J. Pathol. 179, 1373–1384 (2011).

    PubMed 
    PubMed…

  • Read more…