Cohorts
The main dataset used in this study comes from the ROS/MAP cohorts. ROS and MAP are longitudinal cohort studies of aging and AD led by investigators at the Rush Alzheimer’s Disease Center51,52. Participants give written informed consent for annual assessments, signed an Anatomic Gift Act, and a repository consent to allow their data and biospecimens to be repurposed. Each year, participants undergo a detailed medical, neurological, and neuropsychiatric assessment. After death, each participant undergoes a detailed brain autopsy with neuropathologic examination. Both ROS and MAP were approved by the Institutional Review Board of Rush University Medical Center. They share a large common core of data at the item level to allow efficient merging of datasets. ROS/MAP resources can be requested at https://www.radc.rush.edu.
In addition, we also obtained data from three separate…
