An MD/PhD Collaboration to Apply Hyperpolarized 13 C Metabolic MRI for Assessing Renal Tumor Aggressiveness in Patients

Jane Wang, MD and Peder Larson, PhD, faculty members in the UC San Francisco Department of Radiology and Biomedical Imaging are collaborating on a project applying hyperpolarized (HP) carbon 13 (13C) metabolic MRI in patients with renal tumors. The overall goal of their study is to improve risk stratification of localized renal tumors to guide their management and to avoid overtreatment (i.e., avoid unnecessary surgery). They recently achieved two important milestones.

The first milestone is a paper published in Cancer, an international interdisciplinary journal of the American Cancer Society. Renal tumors are frequently discovered incidentally because of the increased use of medical imaging, but it is challenging to risk stratify these tumors to identify which ones require definitive treatment such as surgery versus ones that can safely undergo active surveillance to avoid…

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