Study design
We conducted two experiments (Study A and Study B) to assess Altoida DNS against a set of established NPs as baseline. Study A (ClinicalTrials.gov Identifier: NCT02050464) was a semi-naturalistic observational study that included 29 participants, age 65+, with mild to moderate AD diagnosis recruited in Hirslanden Clinic, ZH, Switzerland. Study B (ClinicalTrials.gov Identifier: NCT02843529) was also a semi-naturalistic observational multicenter study, which included 496 participants (213 MCI and 283 HC), performed in ten European memory clinics and primary care centers, and two primary care community centers in the USA. Thus, a total of 525 participants enrolled in the two studies. These participants were either cognitively healthy (n = 283) or diagnosed with MCI (n = 213) or AD (n = 29). The studies shared similar entry (inclusion/exclusion) criteria and…
