Why do some neurons degenerate and die in Alzheimer’s disease, but not others?

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dementianews
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Why do some neurons degenerate and die in Alzheimer's disease, but not others?
Gladstone scientists uncover evidence that neurons are more sensitive to degeneration when they contain high levels of the protein apoE, which is associated with a higher risk of developing Alzheimer’s disease. Shown here in the lab are Nicole Koutsodendris (left) and Yadong Huang (right), authors of a new study. Credit: Michael Short/Gladstone Institutes

In the brain of a person with Alzheimer’s disease, neurons degenerate and die, slowly eliminating memories and cognitive skills. However, not all neurons are impacted equally. Some types of neurons in certain brain regions are more susceptible, and even among those subtypes—mysteriously—some perish and some do not.

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