Newswise — Irvine, Calif., April 27, 2021 — University of California, Irvine biologists have developed a new genetically engineered mouse model that, unlike its predecessors, is based on the most common form of Alzheimer’s disease. The advance holds promise for making new strides against the neurodegenerative disease as cases continue to soar. Their study appears in the journal, Nature Communications.
Link to study: https://www.nature.com/articles/s41467-021-22624-z
While over 170 Alzheimer’s mouse models have been in use since the 1990s, those models mimic early-onset AD, also known as “familial AD,” which accounts for less than 5 percent of total AD cases. Until recently, scientists introduced mutations found in familial risk human genes, such as the amyloid precursor protein and presenilin 1, into the mouse genome to generate the mouse models. The UCI team…
