How a tangled protein kills brain cells, promotes Alzheimer’s

How a tangled protein kills brain cells, promotes Alzheimer's
Graphical abstract. Credit: Neuron (2021). DOI: 10.1016/j.neuron.2021.03.026

Look deep inside the brain of someone with Alzheimer’s disease, most forms of dementia or the concussion-related syndrome known as chronic traumatic encephalopathy (CTE) and you’ll find a common suspected culprit: stringy, hairball-like tangles of a protein called tau.

Such conditions, collectively known as “tauopathies” strike scores of people across the globe, with Alzheimer’s alone affecting six million people in the United States.

But more than a century after German psychiatrist Alois Alzheimer discovered , scientists still have much to learn about them.

A University of…

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