Korea Brain Research Institute (KBRI, Pann-Ghill Suh (President)) announced that Dr. Kea Joo Lee and Dr. You-Na Jang of the Neural Circuits Research Group have identified the mechanism causing synaptic loss in Alzheimer’s disease as the aberrant expression of RAPGEF2, a synaptic protein.
The results were published on January 2021, in the online early view of Neuropathology and Applied Neurobiology. RAPGEF2 mediates oligomeric Aβ-induced synaptic loss and cognitive dysfunction in the 3xTg-AD mouse model of Alzheimer’s disease
Alzheimer’s disease (AD) accounts for about 75% of dementia cases and is the most common type of…
