Neurodegenerative diseases, such as various forms of senile dementia or amyotrophic lateral sclerosis (ALS), have one thing in common: large amounts of certain RNA-protein complexes (snRNPs) are produced and deposited in the nerve cells of those affected—and this hinders the function of the cells. The overproduction is possibly caused by a malfunction in the assembly of the protein complexes.
How the production of these protein complexes is regulated was unknown…
